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The current Guidelines represent an update, revision, and expansion of the original Guidelines [1], and are based on comprehensive reviews of the best available evidence. The revision process also involved consultation between academic experts in the field of mental health and substance use, consumer groups and clinicians, and as such, the current Guidelines reflect the collective experience of an expert panel of academic researchers, clinicians, consumers and carers (see p.iii). In addition to reviewing, synthesising, and updating the evidence to date, feedback on the original Guidelines was obtained from key-stakeholders, and areas for improvement identified.

Both clinical and scientific knowledge about what treatment modalities may help those with comorbidity has been included, and as such, a variety of psychotherapies and pharmacotherapies are discussed. We have also included discussion of physical activity, some complementary and alternative therapies, as well as e-health interventions. The clinical evidence for the efficacy of these interventions varies greatly, and it is critical to note that although there may be limited scientific evidence to recommend a treatment as best practice, that does not necessarily mean that the treatment is ineffective. That is, the quality of some studies evaluating some interventions is not as rigorous as others, and does not provide adequate support or evidence for clinical guidance.